Defining Reference Design
For a pharmaceutical plant, it might mean we need a specialist in oral solid dose manufacturing, a quality representative and a health and safety specialist.. Based on this initial representation, we can start gathering the knowledge and data that is essential for developing a solution.
The episode highlights the transformative research and development in small molecule Active Pharmaceutical Ingredients, emphasising the generation of new, more complex, and targeted molecules.This revolution is pivotal for advancing the mainstay of essential medicines globally.. 2.
Challenges in traditional manufacturing:.Adrian La Porta discusses the limitations of current manufacturing practices, particularly batch chemistry, in meeting the modern demands for higher volumes, complex products, and faster production at lower costs, all while minimising environmental impact.He points out the inefficiencies and hazards of scaling up production using traditional methods.. 3.
Innovation in process intensification and automation:.The podcast emphasises the shift towards process intensification and automation as solutions to the challenges faced by traditional manufacturing.
These innovations promise to deliver lean and agile manufacturing, reducing waste, improving quality, and enabling the production of more complex molecules more efficiently.. 4.
The future of pharmaceutical manufacturing:.“Everybody right now, if you're an architect or a builder, you should be working on your foundational skills with the baseline, anchor, portfolio products,” she says.. It’s then what she calls the “connective tissue” technology, the tech which forms between those products to connect them to other products, which will be the key to getting from “conceptualisation, design, to make, to operate,” she says.. Productization: building a raft in the ocean of construction.
The process of productising the pieces and parts involved in construction will help inform our understanding of what technological connective tissue is missing, as well as what we need to do to fill in the gaps.. Amy Marks compares the productisation of those elements to building a raft or reef in the middle of the ocean.Whether it be a generator, a panel, a bathroom pod, or something else, productisation will provide something solid to work with inside a sea of fluidity, something we can “actually track through and map…”.
The key, she says, is that the products must be fully defined.We must understand every aspect, including workflows, performance, and sustainability.